Best Pest Control For Trees And Shrubs: Compare 9 Options

#1 · Best Overall

1. BioAdvanced Protect and Feed II Concentrate

• Weight: 2.4 lb
• Form: Liquid

Best for: For liquid annual tree care.

Why it ranks #1: Systemic concentrate claims up to 12 months of protection, feeds plants, and lists pests including emerald ash borers, Japanese beetles, aphids, and leafminers.

A liquid concentrate combining slow-release feeding with systemic insect protection gives BioAdvanced Protect and Feed II a dual-purpose role for trees and shrubs. One application is stated to protect for up to 12 months, and the formula can be used on potted as well as outdoor plants.

The concentrate is measured and mixed for application, while its systemic protection moves from roots toward the plant’s stems and leaves. That route pairs with slow-release nitrogen fertilizer, so the treatment provides listed insect control and season-long nutrition. Named targets include emerald ash borers, Japanese beetles, adelgids, leafminers, aphids, and caterpillars; its up-to-one-year duration suits buyers preferring an annual routine over repeated contact spraying.

Skip it if you prefer a granular format; BioAdvanced 12 Month Tree and Shrub Protect and Feed II Granules offers the same named annual-care role in granules.

Choose this liquid concentrate if you want annual systemic insect protection and slow-release feeding for potted or outdoor trees and shrubs. It requires measuring and mixing, so it suits buyers comfortable preparing a treatment rather than using a ready-to-spray bottle.

Listed on Amazon as: BioAdvanced 12 Month Tree and Shrub Protect and Feed II, Concentrate, 32 Oz, Outdoor Insect Killer

#2 · Best Liquid Feed

2. BioAdvanced 12 Month Protect and Feed

• Weight: 2 lb
• Form: Liquid

Best for: For annual protection plus feeding.

Why it ranks #2: This liquid concentrate combines listed insect control for up to 12 months with slow-release plant food and no-spray application.

One application combines listed insect control with slow-release plant food, giving BioAdvanced Protect and Feed Concentrate a two-part role in tree and shrub care. It provides up to 12 months of protection, and its no-spray application can suit gardeners seeking extended treatment alongside season-long nutrition.

The concentrate is applied without spraying, which changes the workflow for gardeners who prefer a ground-level treatment. Its slow-release fertilizer moves systemically from roots toward branch tips, linking plant feeding with protection against listed insects such as emerald ash borers, Japanese beetles, adelgids, and leafminers. One application is stated to prevent new infestations for up to a year, making this a fit for buyers who want both functions in one treatment.

Skip it if you want a hose-connected ready-to-spray application; BioAdvanced Tree & Shrub Insect Killer Spray uses that format.

Pick this concentrate if you want listed insect protection and slow-release feeding in a no-spray treatment for outdoor or container plants. It suits annual-care routines, but requires a ground-level application rather than hose spraying.

Listed on Amazon as: BioAdvanced 12 Month Tree & Shrub Protect and Feed Concentrate – 32 oz

#3 · Best Annual Drench

3. Bonide Annual Tree and Shrub Control

• Weight: 8.2 lb
• Form: Spray

Best for: For annual root-zone treatment.

Why it ranks #3: The concentrate is mixed with water and poured at the base, with claimed year-long protection and listed use on ornamental and fruit trees.

A pour-at-the-base application carries Bonide’s concentrate through the root zone and into the tree or shrub, avoiding spray application. Its systemic approach is intended to protect listed plants, including fruit, nut, and ornamental trees and shrubs such as roses, apples, peaches, and cherries, against listed insect pests.

Mixing the concentrate with water and pouring it at the base gives gardeners a ground-level application workflow rather than spraying foliage. The product then moves from the roots up through the plant, with listed protection for new growth; the supplied description says protection can last up to one year. That combination suits established trees and shrubs where a once-yearly treatment is preferred, provided the plant and target pest are listed for use.

Skip it if you want a ready-to-spray hose connection; BioAdvanced Tree & Shrub Insect Killer Spray is listed as ready to spray.

Choose this concentrate if you want a ground-applied systemic treatment for listed trees or shrubs, including specified fruit and ornamental plants. It requires mixing, and the plant and pest should match its label.

Listed on Amazon as: Bonide Annual Tree & Shrub Insect Control with Systemaxx, 128 oz Concentrate, Year Long Protection and Insect Killer

#4 · Best Granules

4. BioAdvanced Protect and Feed II Granules

• Weight: 4.54 kg
• Form: Granules

Best for: For granular feed and protection.

Why it ranks #4: Granules combine listed insect control for up to a year with slow-release fertilizer, suiting buyers who prefer a granular format.

Granular formulation sets BioAdvanced Protect and Feed II apart for gardeners who prefer measuring a solid product for tree and shrub care. Its slow-release fertilizer also provides systemic feeding, while one application is stated to protect against listed insects and prevent new infestations for up to a year.

The granules include a built-in measuring cup, supporting measured application before the product is mixed with water according to the supplied directions. Their slow-release fertilizer function links feeding with insect protection, and the product lists pests such as Japanese beetles, adelgids, leafminers, aphids, and caterpillars. This two-in-one approach suits buyers seeking extended care, though it involves measuring and water preparation rather than using a ready-to-spray bottle.

Skip it if you want a liquid concentrate instead of granules; BioAdvanced 12 Month Tree and Shrub Protect and Feed II Concentrate is a liquid option.

This granule option suits tree and shrub owners who want feeding and listed insect protection in one treatment and are comfortable measuring and mixing. Its solid format is the key fit consideration for buyers choosing an application workflow.

Listed on Amazon as: BioAdvanced 12 Month Tree and Shrub Protect and Feed II, Granules, 10 Pound, Tree Fertilizer & Outdoor Insect Killer

#5 · Largest Concentrate

5. Fertilome Tree and Shrub Drench

• Weight: 8.6 lb
• Form: Liquid

Best for: For once-yearly drench routines.

Why it ranks #5: The one-gallon systemic concentrate is designed for outdoor trees and shrubs and claims up to 12 months of protection from listed insects.

A systemic drench applied around the plant base gives ferti-lome Tree & Shrub Drench a straightforward route to treating outdoor residential trees and shrubs. Its stated protection lasts up to 12 months, and the product calls for only one application a year, with early spring or early fall noted as preferred timing.

The liquid concentrate is mixed with water and poured around the base, so application centers on the root area rather than spraying the canopy. That method pairs with systemic protection for up to 12 months against listed insects, including aphids and psyllids. The once-yearly schedule can simplify routine care, while the specified seasonal timing and label rates matter when planning treatment for trees versus shrubs.

Skip it if you need a ready-to-use spray for contact treatment; BioAdvanced Tree & Shrub Insect Killer Spray connects to a garden hose.

This drench fits owners of outdoor residential trees and shrubs who prefer a once-yearly, base-applied systemic treatment. Plan around the recommended early-spring or early-fall timing and follow the label rates for each plant type.

Listed on Amazon as: Fertilome (11207) Tree & Shrub Drench Systemic Insecticide, 1 gal

#6

6. BioAdvanced Fruit and Citrus Control

• Weight: 2 lb
• Form: Liquid

Best for: For fruit and citrus trees.

Why it ranks #6: This concentrate targets listed fruit and citrus pests, including Asian citrus psyllid, and claims prevention of new infestations for up to two months.

A targeted pest list for fruit and citrus plants makes BioAdvanced Fruit & Citrus Tree Insect Control Concentrate a crop-focused choice. It is applied by mixing and pouring at the plant base, and its stated protection against new infestations lasts up to two months on listed plants.

The base-pour application gives this concentrate a ground-level workflow, while its listed uses extend beyond citrus to apple, peach, cherry, and plum trees and several garden crops. It targets a broad set of named pests, including Asian citrus psyllid, citrus leafminers, aphids, and whiteflies, with prevention of new infestations for up to two months. That duration suits targeted seasonal care, not a year-long protection schedule.

Skip it if you want year-long protection for ornamental shrubs; BioAdvanced 12 Month Tree & Shrub Protect and Feed Concentrate lists up to one year.

Choose this concentrate for listed fruit and citrus trees when its named pest targets and base-pour method match your needs. Its stated protection period is up to two months, making it a shorter-duration option than annual treatments.

Listed on Amazon as: BioAdvanced Fruit & Citrus Tree Insect Control Concentrate – 32 oz Bottle

#7

7. BioAdvanced Tree and Shrub Spray

• Weight: 2.1 lb
• Form: Liquid

Best for: For quick hose-connected spraying.

Why it ranks #7: The hose-connected spray offers fast-acting control of listed insects and protection for up to two weeks on trees and shrubs.

A ready-to-spray bottle that connects to a garden hose makes BioAdvanced Tree & Shrub Insect Killer a direct option for treating outdoor trees and shrubs. Its fast-acting formula kills listed insects on contact, while the stated protection period of up to two weeks offers a short follow-through after application.

The hose connection avoids preparing a diluted concentrate separately, making this format practical when you want to apply a liquid treatment across outdoor plants. Contact action targets listed pests such as aphids, adult Japanese beetles, caterpillars, and whiteflies; the formula continues to kill and control listed insects for up to two weeks. That interval is shorter than annual treatments, so it fits buyers prioritizing ready-to-use application over year-long coverage.

Skip it if you need year-long systemic coverage; BioAdvanced 12 Month Tree & Shrub Protect and Feed Concentrate lists protection for up to one year.

This hose-connected spray suits gardeners who want a ready-to-apply treatment for listed pests on outdoor trees and shrubs. Its stated control period is up to two weeks, so it is not an annual-protection option.

Listed on Amazon as: BioAdvanced Tree & Shrub Insect Killer Spray – Outdoor Pest Control – 32 oz

#8

8. Sevin 3-in-1 Flower and Shrub

• Weight: 2.2 lb
• Form: Liquid Ready to Spray

Best for: For combined pest and disease care.

Why it ranks #8: This ready-to-spray product combines insect, mite, and disease control for flowers and shrubs, but its listed scope is less suited to trees.

Three treatment roles in one ready-to-spray formula distinguish Sevin 3-in-1 Flower & Shrub RTS: it addresses insects, mites, and listed diseases. For gardeners caring for flowers and shrubs, that combination can consolidate treatment tasks, with fast-acting action and rain resistance among the stated features.

The ready-to-spray liquid avoids mixing a concentrate, while its insecticide, miticide, and fungicide functions address more than insect damage alone. Listed targets include ants, aphids, and armyworms, plus rust, powdery mildew, and black spots; the product is also described as rain proof and not washing away. This makes it relevant when both pests and fungal problems are on the care list, though treatments must be sprayed evenly and as directed.

Skip it if you need systemic year-long protection for trees; BioAdvanced 12 Month Tree & Shrub Protect and Feed Concentrate lists that use.

Choose Sevin if your flower and shrub routine needs a ready-to-spray option addressing listed insects, mites, and fungal diseases together. Its stated use centers on flowers and shrubs, so it is not the fit for a tree-focused systemic treatment.

Listed on Amazon as: Sevin 3-in-1 Flower & Shrub RTS Insect, Mite, & Disease Control 32 oz

#9

9. BioAdvanced Organics Neem Oil

• Weight: 1.5 lb
• Form: Oil

Best for: For contact spray and fungal care.

Why it ranks #9: The ready-to-use neem oil spray controls listed insects, mites, and fungal diseases, but its repeated spray schedule is less suited to long-term tree protection.

A ready-to-use neem oil spray combines insect, mite, and fungal-disease control in one product, giving BioAdvanced Organics a broad role in garden care. It kills listed insects and mites on contact, while disease prevention requires repeat application on a stated 7–14-day schedule.

The trigger-spray format avoids dilution and is suited to applying the oil directly to plants. Its three-in-one action targets insect and mite life stages from eggs to adults, including aphids, whiteflies, and spider mites, while also addressing listed diseases such as black spot, powdery mildew, rust, and downy mildew. The repeat schedule for disease prevention makes ongoing application part of the routine rather than a once-yearly treatment.

Skip it if you want one annual systemic treatment; BioAdvanced 12 Month Tree and Shrub Protect and Feed II Concentrate lists up to a year of protection.

This spray fits gardeners seeking contact treatment for listed insects and mites alongside fungal-disease control. Be prepared for repeat applications on the stated disease schedule, rather than relying on a single annual treatment.

Listed on Amazon as: BioAdvanced Organics Brand Neem Oil Spray – 24 fl oz